Intra-arterial tenecteplase after successful endovascular recanalisation in patients with acute posterior circulation arterial occlusion (ATTENTION-IA): multicentre randomised controlled trial.

ABSTRACT:

Objective

To assess whether intra-arterial tenecteplase administered after successful endovascular recanalisation improves outcomes in patients with acute arterial occlusion of the posterior circulation.

Design

Multicentre randomised controlled trial.

Setting

31 hospitals in China, 24 January 2023 to 24 August 2023.

Participants

208 patients with successful recanalisation (grade 2b50-3 on the extended thrombolysis in cerebral infarction scale) of an occlusion in the V4 segment of the vertebral artery; proximal, middle, or distal segment of the basilar artery; or P1 segment of the posterior cerebral artery: 104 were randomly allocated to receive tenecteplase and 104 to receive standard care.

Interventions

Intra-arterial tenecteplase (0.0625 mg/kg, maximum

SUBMITTER: Hu W 

PROVIDER: S-EPMC11729139 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature