Serum proteome signatures associated with liver steatosis in adolescents with obesity.

ABSTRACT:

Purpose

Childhood obesity, a pressing global health issue, significantly increases the risk of metabolic complications, including metabolic dysfunction associated with steatotic liver disease (MASLD). Accurate non-invasive tests for early detection and screening of steatosis are crucial. In this study, we explored the serum proteome, identifying proteins as potential biomarkers for inclusion in non-invasive steatosis diagnosis tests.

Methods

Fifty-nine obese adolescents underwent ultrasonography to assess steatosis. Serum samples were collected and analyzed by targeted proteomics with the Proximity Extension Assay technology. Clinical and biochemical parameters were evaluated, and correlations among them, the individuated markers, and steatosis were performed. Receiver opera

SUBMITTER: Giraudi PJ 

PROVIDER: S-EPMC11729140 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature