Fecal Microbial Dysbiosis Is Associated with Colorectal Cancer Risk in a Korean Population.

ABSTRACT:

Purpose

The association between the fecal microbiota and colorectal cancer (CRC) risk has been suggested in epidemiologic studies. However, data from large-scale population-based studies are lacking.

Materials and methods

In this case-control study, we recruited 283 CRC patients from the Center for Colorectal Cancer, National Cancer Center Hospital, Korea to perform 16S rRNA gene sequencing of fecal samples. A total of 283 age- and sex-matched healthy participants were selected from 890 cohort of healthy Koreans that are publicly available (PRJEB33905). The microbial dysbiosis index (MDI) was calculated based on the differentially abundant species. The association between MDI and CRC risk was observed using conditional logistic regression. Sparse Canonical Correlation Analys

SUBMITTER: Kim J 

PROVIDER: S-EPMC11729318 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature