High p16^INK4A expression in glioblastoma is associated with senescence phenotype and better prognosis.

ABSTRACT: Glioblastoma, isocitrate dehydrogenase (IDH)-wildtype (GBM), is the most malignant brain tumor in adults, with limited therapeutic intervention. Previous studies have identified a few prognostic markers for GBM, including the methylation status of O⁶-methylguanine-DNA methyltransferase (MGMT) promoter, TERT promoter mutation, EGFR amplification, and CDKN2A/2B deletion. However, the classification of GBM remains incomplete, necessitating a comprehensive analysis. In this study, we investigated the impact of p16^INK4A expression in GBM and found that p16^INK4A-high GBM exhibits distinct characteristics compared to p16^INK4A-low GBM. Specifically, tumor cells with p16^INK4A-high expression display a senescent phenotype and are correlated with

SUBMITTER: Park SS 

PROVIDER: S-EPMC11729681 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature