Molecular weight of hyaluronic acid crosslinked into biomaterial scaffolds affects angiogenic potential.

ABSTRACT: While hyaluronic acid (HA)-based hydrogels have been used clinically for decades, the mechanisms by which HA exerts molecular weight-dependent bioactivity and how chemical modification and crosslinking may affect molecular weight-dependent bioactivity remain poorly understood. This knowledge gap presents a significant barrier to designing HA hydrogels with predictable bioactivities. As HA has been widely reported to have molecular weight-dependent effects on endothelial cells (ECs), we investigated how the molecular weight of HA in either soluble or crosslinked forms affects angiogenesis and interrogated CD44 clustering on the surface of endothelial cells as a candidate mechanism for these affects. Using soluble HA, our results show high molecular weight (HMW) HA, but not low molecular wei

SUBMITTER: Karam J 

PROVIDER: S-EPMC11729822 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature