Histology-Specific Clinical Trial of Lenvatinib and Pembrolizumab in Patients with Sarcoma.

ABSTRACT:

Purpose

Survival of patients with metastatic sarcoma remains poor, and there is a pressing need for new therapies. Most sarcoma subtypes are not responsive to immune checkpoint inhibition alone. Lenvatinib, a multireceptor tyrosine kinase inhibitor targeting tumor vasculature, has an immunomodulatory activity that contributes to its antitumor effects. Therefore, we hypothesized that a combination of lenvatinib and pembrolizumab would lead to improved clinical outcomes in patients with sarcoma.

Patients and methods

This was an open-label, single-arm study of lenvatinib and pembrolizumab in the following cohorts: (A) leiomyosarcoma, (B) undifferentiated pleomorphic sarcoma (UPS), (C) vascular sarcomas (angiosarcoma and epithelioid hemangioendothelioma), (D) synovial sarcoma or

SUBMITTER: Movva S 

PROVIDER: S-EPMC11730159 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature