Development of a latency model for HIV-1 subtype C and the impact of long terminal repeat element genetic variation on latency reversal.

ABSTRACT: Sub-Saharan Africa accounts for almost 70 % of people living with HIV (PLWH) worldwide, with the greatest numbers centred in South Africa where 98 % of infections are caused by subtype C (HIV-1C). However, HIV-1 subtype B (HIV-1B), prevalent in Europe and North America, has been the focus of most cure research and testing despite making up only 12 % of HIV-1 infections globally. Development of latency models for non-subtype B viruses is a necessary step to address this disproportionate focus. Furthermore, the impact of genetic variation between viral subtypes, specifically within the long terminal repeat (LTR) element of the viral transcriptional promoter on latency reversal, remains unclear. To address this scientific gap, we constructed a minimal genome retroviral vector expressing HIV-1

SUBMITTER: Maikoo S 

PROVIDER: S-EPMC11730875 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature