The TyrA family of aromatic-pathway dehydrogenases in phylogenetic context.

ABSTRACT:

Background

The TyrA protein family includes members that catalyze two dehydrogenase reactions in distinct pathways leading to L-tyrosine and a third reaction that is not part of tyrosine biosynthesis. Family members share a catalytic core region of about 30 kDa, where inhibitors operate competitively by acting as substrate mimics. This protein family typifies many that are challenging for bioinformatic analysis because of relatively modest sequence conservation and small size.

Results

Phylogenetic relationships of TyrA domains were evaluated in the context of combinatorial patterns of specificity for the two substrates, as well as the presence or absence of a variety of fusions. An interactive tool is provided for prediction of substrate specificity. Interactive alignments f

SUBMITTER: Song J 

PROVIDER: S-EPMC1173090 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature