An antisense-long-noncoding-RNA modulates p75^NTR expression levels during neuronal polarization.

ABSTRACT: Proper polarization of newly generated neurons is a critical process for neural network formation and brain development. The pan-neurotrophin p75^NTR receptor plays a key role in this process localizing asymmetrically in one of the differentiating neurites and specifying its axonal identity in response to neurotrophins. During axonal specification, p75^NTR levels are transiently modulated, yet the molecular mechanisms underlying this process are not known. Here, we identified a previously uncharacterized natural antisense transcript, AS-p75, encoded within the p75NGFR mouse gene. Using an in vitro model of polarizing murine neurons, we found that AS-p75 and p75^NTR display divergent expression profiles and that p75^NTR expression levels increa

SUBMITTER: De Paolis V 

PROVIDER: S-EPMC11730960 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature