On the use of haplotype phylogeny to detect disease susceptibility loci.

ABSTRACT:

Background

The cladistic approach proposed by Templeton has been presented as promising for the study of the genetic factors involved in common diseases. This approach allows the joint study of multiple markers within a gene by considering haplotypes and grouping them in nested clades. The idea is to search for clades with an excess of cases as compared to the whole sample and to identify the mutations defining these clades as potential candidate disease susceptibility sites. However, the performance of this approach for the study of the genetic factors involved in complex diseases has never been studied.

Results

In this paper, we propose a new method to perform such a cladistic analysis and we estimate its power through simulations. We show that under models where the susce

SUBMITTER: Bardel C 

PROVIDER: S-EPMC1173100 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature