Venous compression causes chronic cerebral ischaemia in normal pressure hydrocephalus patients.

ABSTRACT:

Background

Cerebral autoregulation is a robust regulatory mechanism that stabilizes cerebral blood flow in response to reduced blood pressure, thereby preventing cerebral ischaemia. Scientists have long believed that cerebral autoregulation also stabilizes cerebral blood flow against increases in intracranial pressure, which is another component that determines cerebral perfusion pressure. However, this idea was inconsistent with the complex pathogenesis of normal pressure hydrocephalus, which includes components of chronic cerebral ischaemia due to mild increases in intracranial pressure.

Methods

Twenty-one patients who underwent ventriculoperitoneal shunt surgery for normal pressure hydrocephalus were included in this study. To determine the pressure setting of the Codman-

SUBMITTER: Ohmura T 

PROVIDER: S-EPMC11731173 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature