Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy.

ABSTRACT: Reactive oxygen species (ROS)-mediated anticancer modalities, which disturb the redox balance of cancer cells through multi-pathway simulations, hold great promise for effective cancer management. Among these, cooperative physical and biochemical activation strategies have attracted increasing attention because of their spatiotemporal controllability, low toxicity, and high therapeutic efficacy. Herein, we demonstrate a nanogel complex as a multilevel ROS-producing system by integrating chloroperoxidase (CPO) into gold nanorod (AuNR)-based nanogels (ANGs) for cascade-amplifying photothermal-enzymatic synergistic tumor therapy. Benefiting from photothermal-induced hyperthermia upon near-infrared (NIR) laser exposure, the exogenous ROS (including H₂O₂) were boosted by t

SUBMITTER: Ding L 

PROVIDER: S-EPMC11731229 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature