Controlled delivery of mesenchymal stem cells via biodegradable scaffolds for fracture healing.

ABSTRACT: Biodegradable controlled delivery systems for mesenchymal stem cells (MSCs) have emerged as novel advancements in the field of regenerative medicine, particularly for accelerating bone fracture healing. This detailed study emphasizes the importance of quick and adequate fracture treatment and the limitations of existing methods. New approaches employing biodegradable scaffolds can be placed within a fracture to serve as a mechanical support and allow controlled release of in situ MSCs and bioactive agents. They are made up of polymers and composites which degrade over time, aiding in natural tissue regrowth. The fabrication methods, including 3D printing, electrospinning, and solvent casting, with particulate leaching that enable precise control over scaffold architecture and properties, a

SUBMITTER: Han D 

PROVIDER: S-EPMC11731254 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature