Integrin α8 is a useful cell surface marker of alveolar lipofibroblasts.

ABSTRACT:

Background

Recent advances in comprehensive gene analysis revealed the heterogeneity of mouse lung fibroblasts. However, direct comparisons between these subpopulations are limited due to challenges in isolating target subpopulations without gene-specific reporter mouse lines. In addition, the properties of lung lipofibroblasts remain unclear, particularly regarding the appropriate cell surface marker and the niche capacity for alveolar epithelial cell type 2 (AT2), an alveolar tissue stem cell.

Methods and results

Using cell surface markers applicable even into wild-type mouse lungs, we could classify PDGFRα⁺ total lung resident fibroblasts into at least two major distinct subpopulations: integrin α8 (ITGA8)⁺ and SCA-1⁺ fibroblasts. We analy

SUBMITTER: Fukada A 

PROVIDER: S-EPMC11731379 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature