Vaccination with formulations targeting Eimeria maxima and Clostridium perfringens conferred comprehensive protection using a dual-infection challenge model of necrotic enteritis.

ABSTRACT: With increasing regulations restricting antibiotic use in animal feed, the need for alternative strategies to prevent and manage necrotic enteritis (NE) has become imperative. As a result, developing effective vaccines has emerged as a top priority for broiler chicken health management. Coccidial infections are a well-established predisposing factor for NE, underscoring the importance of controlling coccidiosis to help mitigate NE outbreaks. This research aimed to investigate the protective efficacy of vaccine preparations containing Eimeria maxima elongation factor-1α and a multicomponent antigen cocktail of Clostridium perfringens, including a single collagen adhesion protein (CpCna) and two chimeric proteins: CpNA (NetB-Alpha-toxin) and CpFZ (Fructose-1,6-bisphosphate aldolase-Zinc meta

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC11731461 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature