A deoxyfluoroalkylation-aromatization strategy to access fluoroalkyl arenes.
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ABSTRACT: Fluoroalkyl arenes (Ar-RF) are valuable substructures present in several FDA-approved drugs, patents, agrochemicals, and materials, and complementary strategies that enable access to a broad spectrum of Ar-RF compounds benefit these applied fields. Herein, we report a deoxyfluoroalkylation-aromatization strategy to convert cyclohexanones into broad-spectrum Ar-RF containing compounds. Generally, the fluoroalkyl sources were activated to participate in a 1,2-addition reaction followed by aromatization in a sequence that contrasts more common preparations of these Ar-RF compounds, such as (i) transition-metal catalyzed cross-coupling reactions of aryl electrophiles and nucleophiles, and (ii) radical fluoroalkylation reactions of C-H bonds of arenes
SUBMITTER: Bhattarai P
PROVIDER: S-EPMC11731486 | biostudies-literature | 2025 Feb
REPOSITORIES: biostudies-literature
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