The virome composition of respiratory tract changes in school-aged children with Mycoplasma pneumoniae infection.

ABSTRACT:

Background

Mycoplasma pneumoniae (MP) is a common pathogen for respiratory infections in children. Previous studies have reported respiratory tract microbial disturbances associated with MP infection (MPI); however, since the COVID-19 pandemic, respiratory virome data in school-aged children with MPI remains insufficient. This study aims to explore the changes in the respiratory virome caused by MPI after the COVID-19 pandemic to enrich local epidemiological data.

Methods

Clinical samples from 70 children with MPI (70 throat swab samples and 70 bronchoalveolar lavage fluid (BALF) samples) and 78 healthy controls (78 throat swab samples) were analyzed using viral metagenomics. Virus reads were calculated and normalized using MEGAN.6, followed by statistical analysis.

Resul

SUBMITTER: Zhang D 

PROVIDER: S-EPMC11731546 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature