Response to Central Boost Radiation Therapy in Unresectable Retroperitoneal Sarcoma: A Case Series.

ABSTRACT:

Purpose

Optimal treatment of retroperitoneal sarcoma (RPS) remains undefined. Here, we report the feasibility of using high-dose boost radiation (3-4 Gy) to the central part of the tumor in patients with unresectable RPS.

Methods and materials

Five patients with unresectable RPS were treated with radiation therapy using a central boost technique with intensity modulated radiation therapy. On average, doses of 25 Gy to 45 Gy were delivered to the outer part of the tumor (planning target volume 1), while the central part of the tumor (planning target volume 2) received a 56 Gy to 75 Gy physical dose, which translates to a 62.67 Gy to 87.5 Gy equivalent dose in 2 Gy fractions (EQD2). To minimize radiation toxicity to the adjacent bowel and other organs, we used sequential, inte

SUBMITTER: Burner DN 

PROVIDER: S-EPMC11731575 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature