Keratinocyte-derived extracellular vesicles in painful diabetic neuropathy.

ABSTRACT: Painful diabetic neuropathy (PDN) is a challenging complication of diabetes with patients experiencing a painful and burning sensation in their extremities. Existing treatments provide limited relief without addressing the underlying mechanisms of the disease. PDN involves the gradual degeneration of nerve fibers in the skin. Keratinocytes, the most abundant epidermal cell type, are closely positioned to cutaneous nerve terminals, suggesting the possibility of bi-directional communication. Extracellular vesicles are lipid-bilayer encapsulated nanovesicles released from many cell types that mediate cell to cell communication. The role of keratinocyte-derived extracellular vesicles (KDEVs) in influencing signaling between the skin and cutaneous nerve terminals and their contribution to the g

SUBMITTER: Coy-Dibley J 

PROVIDER: S-EPMC11731614 | biostudies-literature | 2025 Jan-Jun

REPOSITORIES: biostudies-literature