Primary Mediastinal Synovial Sarcoma with Pericardial Involvement: A Case Report.

ABSTRACT:

Introduction

Synovial sarcoma is a rare, malignant neoplasm accounting for approximately 5-10% of all soft tissue sarcomas. Synovial sarcomas generally occur in the extremities of adolescent or young adult (AYA)-aged patients; however, they have been reported to affect virtually every organ system. The mediastinum is an exceptionally rare location for synovial sarcoma and malignant pericardial effusions occurring secondary to synovial sarcoma can occur.

Case presentation

This case describes a 29-year-old male who presented with 3 weeks of dyspnea and leg swelling. An echocardiogram demonstrated a large pericardial effusion with early tamponade physiology. A subsequent pericardiocentesis returned a lymphocytic predominance with negative flow cytometry and cytology. Cross-sect

SUBMITTER: Michaels KC 

PROVIDER: S-EPMC11731899 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature