Successful Management of Post-Thymectomy Pure Red Cell Aplasia with Rituximab: A Case Report.

ABSTRACT:

Background

Pure red cell aplasia (PRCA) is a rare cause of anemia characterized by decreased red blood cell production, often associated with thymomas. While thymectomy is commonly performed to treat thymoma-associated PRCA, the development of PRCA post-thymectomy is less understood.

Case presentation

We present a case of a 25-year-old woman who developed PRCA and autoimmune diabetes mellitus (DM) following radical thymectomy for malignant thymoma. Initial treatment with prednisolone showed minimal improvement, leading to the inclusion of rituximab. This combination resulted in a significant increase in reticulocyte counts and transfusion independence.

Discussion

This case highlights the potential for PRCA to develop after thymectomy and the challenges of treating PRC

SUBMITTER: Abdulgayoom M 

PROVIDER: S-EPMC11731903 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature