Secreted and surface proteome and transcriptome of Opisthorchis felineus.

ABSTRACT:

Introduction

Opisthorchis felineus, Opisthorchis viverrini, and Clonorchis sinensis are the most medically important species of fish-borne zoonotic trematodes. O. felineus is endemic to the river plains of Western Siberia and Eastern Europe, and it is estimated that more than 1.6 million people could be infected with this parasite. Chronic opisthorchiasis may lead to significant gastrointestinal and hepatobiliary pathology. This study aimed to identify and characterize proteins from the secreted and tegumental proteomes of O. felineus.

Methods

Adult flukes were collected from experimentally infected hamsters and cultured in vitro in serum-free media. We extracted proteins from different compartments of the O. felineus secretome, incl

SUBMITTER: Wong Y 

PROVIDER: S-EPMC11732047 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature