Epigenetic Upregulation of Carotid Body Angiotensin Signaling Increases Blood Pressure.

ABSTRACT:

Background

Epigenetic changes can be shaped by a wide array of environmental cues, maternal health, and behaviors. One of the most detrimental behaviors to the developing fetus is nicotine exposure. Perinatal nicotine exposure remains a significant risk factor for cardiovascular health and, in particular, hypertension. Increased basal carotid body (CB) activity and excitation are significant contributors to hypertension. This study investigated the epigenetic changes to CB activity induced by perinatal nicotine exposure resulting in CB-mediated hypertension.

Methods

We used a rodent model of perinatal nicotine exposure and cell culture methods.

Results

We show that the AgtR1 (angiotensin II type 1 receptor) is upregulated in the carotid bodies of nicotine-exposed offs

SUBMITTER: Zhu F 

PROVIDER: S-EPMC11732265 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature