Flavonoids of <i>Tetrastigma hemsleyanum</i> Diels et Gilg Against Acute Hepatic Injury by Blocking PI3K/AKT Signaling Pathway.

ABSTRACT: Objective: This study aims to investigate the mechanism of Tetrastigma hemsleyanum Diels et Gilg flavonoids (THF) on acute hepatic injury (AHI). Methods: First, high-performance liquid chromatography (HPLC) fingerprints were established to obtain the main chemical components of THF. According to the network pharmacology databases, collect active targets of AHI and potential targets. Using interaction targets to construct a protein-protein interaction (PPI) network, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. Finally, the affinity between the core targets and the main active ingredients was verified by molecular docking. Next, verified network pharmacology predictions with animal experiments. Mice were treated w

SUBMITTER: Li L 

PROVIDER: S-EPMC11732288 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature