Human microbiome-derived peptide affects the development of experimental autoimmune encephalomyelitis via molecular mimicry.

ABSTRACT:

Background

Gut commensal microbiota has been identified as a potential environmental risk factor for multiple sclerosis (MS), and numerous studies have linked the commensal microorganism with the onset of MS. However, little is known about the mechanisms underlying the gut microbiome and host-immune system interaction.

Methods

We employed bioinformatics methodologies to identify human microbial-derived peptides by analyzing their similarity to the MHC II-TCR binding patterns of self-antigens. Subsequently, we conducted a range of in vitro and in vivo assays to assess the encephalitogenic potential of these microbial-derived peptides.

Findings

We analyzed 304,246 human microbiome genomes and 103 metagenomes collected from the MS cohort and identified 731 nonredundant a

SUBMITTER: Ma X 

PROVIDER: S-EPMC11732510 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature