Emerging and characterization of a novel fowl adenovirus 4 strain with open reading frame 19 (ORF19) in diseased chickens from China.

ABSTRACT: The highly virulent genotype fowl adenovirus 4 (FAdV-4), associated with severe hydropericardium hepatitis syndrome (HHS) in poultry from China, is characterized by a large deletion of 1966 bp (1966-del), including losses of ORF19 and ORF27. However, how this virus originated remains unclear. In this study, a novel FAdV-4 strain, HNU-XXY-2019, from diseased chickens, which has a genome size of 45669 bp and is approximately 1966 bp longer than the known FAdV-4 genome from China, was isolated and characterized. Forty-eight unique amino acid substitutions were revealed in protein-coding regions, including 10 substitutions in the Fiber 2 protein, which is reported to reside in the virulence gene. Phylogenetic analyses revealed that HNU-XXY-2019 was located in an evolutionary branch between clu

SUBMITTER: Liao JY 

PROVIDER: S-EPMC11732551 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature