Effect of adipose mesenchymal stem cell-derived exosomes on allergic rhinitis in mice.

ABSTRACT:

Background

At present, the treatment for allergic rhinitis (AR) is only limited to symptom relief, and AR is not able be cured. It is important to find new therapeutic regimens for AR.

Objective

To explore the effect of adipose mesenchymal stem cell-derived exosomes (AMSC-exos) on AR in mice.

Methods

Primary human AMSCs were cultured up to fourth or fifth passage AMSCs which were used to extract AMSC-exos by ultracentrifugation. The AMSC-exos were identified in size, morphology and surface marker proteins. AR mouse models were made, and then effects of the AMSC-exos on AR mouse models were observed by injection of AMSC-exos into their tail veins. A total of 21 mice were divided into normal mice with injection of phosphate buffered saline (PBS) group (Normal + PBS grou

SUBMITTER: Xu X 

PROVIDER: S-EPMC11732663 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature