The BEN domain protein LIN-14 coordinates neuromuscular positioning during epidermal maturation.

ABSTRACT: Development and function of an organism depend on coordinated inter-tissue interaction. How such interactions are maintained during tissue renewal and reorganization remains poorly understood. Here, we find that Caenorhabditis elegans BEN domain transcription factor LIN-14 is required in epidermis for maintaining the position of motor neurons and muscles during developmental tissue reorganization. lin-14 loss of function (lf) mutants display highly penetrant ventral neuromuscular mispositioning. These defects arise post-embryonically during first larval (L1) stage as the maturing epidermis replaces the embryonic ventral epidermis. Tissue-specific and temporally controlled depletion experiments indicate LIN-14 acts within the epidermis for ventral neuromuscular position

SUBMITTER: Jin EJ 

PROVIDER: S-EPMC11732705 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature