Utility of pre-procedural [^99mTc]TcMAA SPECT/CT Multicompartment Dosimetry for Treatment Planning of ⁹⁰Y Glass microspheres in patients with Hepatocellular Carcinoma: comparison of anatomic versus [^99mTc]TcMAA-based Segmentation.

ABSTRACT:

Purpose

Pre-treatment [^99mTc]TcMAA-based radioembolization treatment planning using multicompartment dosimetry involves the definition of the tumor and normal tissue compartments and calculation of the prescribed absorbed doses. The aim was to compare the real-world utility of anatomic and [^99mTc]TcMAA-based segmentation of tumor and normal tissue compartments.

Materials and methods

Included patients had HCC treated by glass [⁹⁰Y]yttrium microspheres, ≥ 1 tumor, ≥ 3 cm diameter and [^99mTc]TcMAA SPECT/CT imaging before treatment. Segmentation was performed retrospectively using dedicated dosimetry software: (1) anatomic (diagnostic CT/MRI-based), and (2) [^99mTc]TcMAA threshold-based (i.e., using an activity-isocontour thr

SUBMITTER: Lam M 

PROVIDER: S-EPMC11732885 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature