Decreased STING predicts adverse efficacy in bortezomib regimens and poor survival in multiple myeloma.

ABSTRACT:

Purpose

STING (stimulator of interferon genes) is involved in viral and bacterial defense through interferon pathway and innate immunity. Increased susceptibility to infection is a common manifestation of multiple myeloma (MM). Thus, we aimed to explore the clinical significance and possible mechanism of STING in MM.

Materials and methods

Immunohistochemistry and qPCR were used to detect STING expression in the bone marrow of MM patients, and flow cytometry was used to detect the amount of intracellular STING. All data were analyzed with clinical characteristics.

Results

STING expression was remarkably reduced in MM tissues compared to normal tissues and was not associated with stage. Multivariate analysis identified STING as an independent prognostic factor in MM pat

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11732914 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature