Autoimmune diseases and the risk and prognosis of latent autoimmune diabetes in adults.

ABSTRACT:

Aims/hypothesis

The aim of this study was to clarify the impact of autoimmune disease (AD) comorbidity on the risk and prognosis of latent autoimmune diabetes in adults (LADA).

Methods

We used data from a Swedish study comprising newly diagnosed cases of LADA (n=586, stratified into LADA^low and LADA^high by autoantibody levels), type 2 diabetes (n=2003) and matched control participants (n=2355). Information on 33 ADs and diabetic retinopathy was obtained by linkage to regional and national registers. We estimated the ORs for LADA and type 2 diabetes in relation to ADs before diabetes diagnosis, and the HRs for diabetic retinopathy after diabetes diagnosis. We performed functional pathway analyses to explore biological mechanisms driving the associations.

SUBMITTER: Santoso C 

PROVIDER: S-EPMC11732938 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature