Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival.

ABSTRACT: Glioma is a highly fatal and heterogeneous brain tumor with few known risk factors. Our study examines genetically predicted variability in blood cell indices in relation to glioma risk and survival in 3418 cases and 8156 controls. We find that increased platelet to lymphocyte ratio (PLR) confers an increased risk of glioma (odds ratio (OR) = 1.25, p = 0.005), especially tumors with isocitrate dehydrogenase (IDH) mutations (OR = 1.38, p = 0.007) and IDH_mut 1p/19q intact (IDH_mut-intact OR = 1.53, p = 0.004) tumors. Genetically inferred increased counts of lymphocytes (IDH_mut-intact OR = 0.70, p = 0.004) and neutrophils (IDH_mut OR = 0.69, p = 0.019; IDH_mut-intact OR = 0.60, p = 0.009) show inverse associations with risk, which may reflec

SUBMITTER: Kachuri L 

PROVIDER: S-EPMC11732991 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature