Multi-omic insights into molecular mechanism and therapeutic targets in spinocerebellar ataxia type 7.

ABSTRACT: Recent advances in molecular science have significantly enlightened our mechanistic understanding of spinocerebellar ataxia type 7. To further close remaining gaps, we performed a multi-omics analysis using SCA7^266Q/5Q mice. Entire brain tissue samples were collected from 12-week-old mice, and RNA sequencing, methylation analysis, and proteomic analysis were performed. Results were integrated to identify genes with identical trends in expression across all three analyses. Data from RNA sequencing and methylation analysis revealed 58 significantly hypomethylated-upregulated genes and 62 hypermethylated-downregulated genes, mostly enriched in GO terms of regulation of axonogenesis, channel activity, and monoamine signaling. In the proteomic analysis, 211 upregulated and 281 downre

SUBMITTER: Ahn SH 

PROVIDER: S-EPMC11733039 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature