Prevalence and Predictors of Tuberculosis Infection in Children and Adolescents in Rural Uganda: A Cross-sectional Study.

ABSTRACT:

Background

Much of the latent tuberculosis (TB) reservoir is established in childhood and adolescence. Yet, age-specific data on prevalence and predictors of infection in this population are sparse and needed to guide prevention and case finding.

Methods

From December 2021 to June 2023, we measured TB infection in children 1-17 years in 25 villages in rural Southwestern Uganda. We defined TB infection as a positive QuantiFERON Gold Plus Test (QFT). We estimated overall and age-stratified population-level prevalence and adjusted risk ratios (aRR) of TB infection for individual, household, and community-based predictors, accounting for age, TB contact, and clustering by household.

Results

Estimated TB infection prevalence was 9.6% [95% confidence interval (CI): 8.7-10.5

SUBMITTER: Kakande E 

PROVIDER: S-EPMC11733060 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature