Transcatheter Edge-to-Edge Repair for Severe Isolated Tricuspid Regurgitation: The Tri.Fr Randomized Clinical Trial.

ABSTRACT:

Importance

Correction of tricuspid regurgitation using tricuspid transcatheter edge-to-edge repair (T-TEER) in addition to guideline-directed optimized medical therapy (OMT) may improve clinical outcomes.

Objective

To evaluate the efficacy of T-TEER + OMT vs OMT alone in patients with severe, symptomatic tricuspid regurgitation.

Design, setting, and participants

Investigator-initiated, prospective, randomized (1:1) trial evaluating T-TEER + OMT vs OMT alone in adult patients with severe, symptomatic tricuspid regurgitation. The trial was conducted at 24 centers in France and Belgium (March 2021 to March 2023; latest follow-up in April 2024).

Intervention

Patients were randomized to T-TEER + OMT or OMT alone.

Main outcomes and measures

The primary outcome

SUBMITTER: Donal E 

PROVIDER: S-EPMC11733701 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature