Role of CD47 gene expression in colorectal cancer: a comprehensive molecular profiling study.

ABSTRACT:

Background

In patients with colorectal cancer (CRC), the therapeutic effects of conventional immune checkpoint inhibitors targeting the adaptive immune system are largely limited to those with microsatellite instability-high tumors. Meanwhile, new immunotherapies targeting the innate immune system are attracting increasing attention. CD47 is a representative innate immune checkpoint involved in the evasion of tumor cell phagocytosis by macrophages. This large-scale study comprehensively examined the molecular significance of CD47 gene expression in CRC.

Methods

We analyzed the next-generation sequencing data of DNA and RNA from 14,287 CRC cases included in the data set of a commercial Clinical Laboratory Improvement Amendments-certified laboratory (Caris Life Sciences

SUBMITTER: Arai H 

PROVIDER: S-EPMC11733795 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature