Shear stress effects on epididymal epithelial cell via primary cilia mechanosensory signaling.

ABSTRACT: Shear stress, resulting from fluid flow, is a fundamental mechanical stimulus affecting various cellular functions. The epididymis, essential for sperm maturation, offers a compelling model to study the effects of shear stress on cellular behavior. This organ undergoes extensive proliferation and differentiation until puberty, achieving full functionality as spermatozoa commence their post-testicular maturation. Although the mechanical tension exerted by testicular fluid is hypothesized to drive epithelial proliferation and differentiation, the precise mechanisms remain unclear. Here we assessed whether the responsiveness of the epididymal cells to shear stress depends on functional primary cilia by combining microfluidic strategies on immortalized epididymal cells, calcium signaling assay

SUBMITTER: Fakhari S 

PROVIDER: S-EPMC11733861 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature