Fungal symbiont transmitted by free-living mice promotes type 2 immunity.

ABSTRACT: The gut mycobiota is crucial for intestinal homeostasis and immune function¹. Yet its variability and inconsistent fungal colonization of laboratory mice hinders the study of the evolutionary and immune processes that underpin commensalism^2,3. Here, we show that Kazachstania pintolopesii is a fungal commensal in wild urban and rural mice, with an exceptional ability to colonize the mouse gastrointestinal tract and dominate the gut mycobiome. Kazachstania pintolopesii colonization occurs in a bacteria-independent manner, results in enhanced colonization resistance to other fungi and is shielded from host immune surveillance, allowing commensal presence. Following changes in the mucosal environment, K. pintolopesii colonization triggers a type 2 immune response in mice

SUBMITTER: Liao Y 

PROVIDER: S-EPMC11733984 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature