Blood absolute lymphocyte count and trajectory are important in understanding severe COVID-19.

ABSTRACT:

Background

Low blood absolute lymphocyte count (ALC) may predict severe COVID-19 outcomes. Knowledge gaps remain regarding the relationship of ALC trajectory with clinical outcomes and factors associated with lymphopenia.

Methods

Our post hoc analysis of the Therapeutics for Inpatients with COVID-19 platform trial utilized proportional hazards models to assess relationships between Day (D) 0 lymphopenia (ALC < 0.9 cells/uL), D0 severe lymphopenia (ALC < 0.5 cells/uL) or lymphopenia trajectory between D0 and D5 with mortality and secondary infections, and with sustained recovery using Fine-Gray models. Logistic regression was used to assess relationships between clinical variables and D0 lymphopenia or lymphopenia trajectory.

Results

D0 lymphopenia (1426/2579) and seve

SUBMITTER: Paules CI 

PROVIDER: S-EPMC11734232 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature