Transcriptome sequencing reveals regulatory genes associated with neurogenic hearing loss.

ABSTRACT: Hearing loss is a prevalent condition with a significant impact on individuals' quality of life. However, comprehensive studies investigating the differential gene expression and regulatory mechanisms associated with hearing loss are lacking, particularly in the context of diverse patient samples. In this study, we integrated data from 10 patients across different regions, age groups, and genders, with their data retrieved from a public transcriptome database, to explore the molecular basis of hearing loss. These samples are mainly from fibroblasts and keratinocytes. Through differential gene expression analysis, we identified key genes, including ICAM1, SLC1A1, and CD24, which have already been shown to play important roles in neurogenic hearing loss. Furthermore, we predicted potential t

SUBMITTER: Jia F 

PROVIDER: S-EPMC11734420 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature