Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease.

ABSTRACT: The largest risk factor for dementia is age. Heterochronic blood exchange studies have uncovered age-related blood factors that demonstrate 'pro-aging' or 'pro-youthful' effects on the mouse brain. The clinical relevance and combined effects of these factors for humans is unclear. We examined five previously identified brain rejuvenation factors in cerebrospinal fluid of adults with autosomal dominant forms of frontotemporal dementia and sporadic Alzheimer's disease. Our frontotemporal dementia cohort included 100 observationally followed adults carrying autosomal dominant frontotemporal dementia mutations (M_age = 49.6; 50% female; 43% C9orf72, 24% GRN, 33% MAPT) and 62 non-carriers (M_age = 52.6; 45% female) with cerebrospinal fluid analysed on So

SUBMITTER: Casaletto KB 

PROVIDER: S-EPMC11734525 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature