Transferability of Single- and Cross-Tissue Transcriptome Imputation Models Across Ancestry Groups.

ABSTRACT: Transcriptome-wide association studies (TWAS) investigate the links between genetically regulated gene expression and complex traits. TWAS involves imputing gene expression using expression quantitative trait loci (eQTL) as predictors and testing the association between the imputed expression and the trait. The effectiveness of TWAS depends on the accuracy of these imputation models, which require genotype and gene expression data from the same samples. However, publicly accessible resources, such as the Genotype Tissue Expression (GTEx) Project, are biased toward individuals of European ancestry, potentially reducing prediction accuracy into other ancestry groups. This study explored eQTL transferability across ancestry groups by comparing two imputation models: PrediXcan (tissue-specific

SUBMITTER: Pagnuco I 

PROVIDER: S-EPMC11734644 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature