NF-<i>κ</i>B Inhibitory Activity of the Di-Hydroxy Derivative of Piperlongumine (PL-18).

ABSTRACT: Inflammation is a critical response of the immune system to infection or injury, serving to repair and restore tissue homeostasis. While acute inflammation generally protects against harmful stimuli, prolonged and chronic inflammation have detrimental effects and disrupts tissue homeostasis. Due to the complex and multifactorial etiology of chronic inflammation, effective treatment remains elusive. We found that piperlongumine (PL)-18, a di-hydroxy derivative of PL from long pepper, inhibits the nuclear factor kappa B (NF-kB), a master transcription factor of numerous components of the inflammatory response. NF-kB was inhibited by PL-18 in two human cell-lines, L428 and A549, by preventing the nuclear translocation of p65 NF-kB. We also found that IκB kinase (IK

SUBMITTER: Schlichter Kadosh Y 

PROVIDER: S-EPMC11735059 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature