Efficacy of Amitriptyline in Irritable Bowel Syndrome: A Systematic Review and Meta-analysis.

ABSTRACT:

Background/aims

Amitriptyline is prescribed off-label for irritable bowel syndrome (IBS). We conducted a meta-analysis to assess its efficacy.

Methods

A systematic literature review was conducted until November 10, 2023, using MEDLINE, Embase, Cochrane Library, and Web of Science to study the efficacy of amitriptyline in patients with IBS. We included all randomized controlled trials that compared amitriptyline to placebo. Revised Cochrane risk-of-bias tool was used to assess the quality of studies. Meta-analyses were performed using a bivariate random-effects model. Statistical analyses were performed using R Software 4.2.3 and heterogeneity was assessed with I2 statistics.

Results

Seven trials were included with 796 patients (61% female). Amitriptyline was associate

SUBMITTER: Iqbal M 

PROVIDER: S-EPMC11735204 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature