<i>APOL1</i> Bi- and Monoallelic Variants and Chronic Kidney Disease in West Africans.

ABSTRACT:

Background

Apolipoprotein L1 gene (APOL1) variants are risk factors for chronic kidney disease (CKD) among Black Americans. Data are sparse on the genetic epidemiology of CKD and the clinical association of APOL1 variants with CKD in West Africans, a major group in the Black population.

Methods

We conducted a case-control study involving participants from Ghana and Nigeria who had CKD stages 2 through 5, biopsy-proven glomerular disease, or no kidney disease. We analyzed the association of CKD with APOL1 variants among participants with high-risk genotypes (two APOL1 risk alleles) and those with low-risk genotypes (fewer than two APOL1 risk alleles) by fitting logistic-regression models that controlled for covariates, including clinical sit

SUBMITTER: Gbadegesin RA 

PROVIDER: S-EPMC11735277 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature