Hypertensive Disorders of Pregnancy and Brain Health in Midlife: The CARDIA Study.

ABSTRACT:

Background

To understand the role of hypertensive disorders of pregnancy (HDP), including preeclampsia and gestational hypertension (GH), in brain health earlier in life, we investigated the association of HDP with midlife cognition and brain health.

Methods

We studied a prospective cohort of women, baseline age 18 to 30 years, who were assessed at study years 25 and 30 with a cognitive battery and a subset with brain magnetic resonance imaging. A history of HDP was defined based on self-report. We conducted linear regression to assess the association of a history of preeclampsia, GH, or no HDP with cognition and brain magnetic resonance imaging white matter hyperintensities.

Results

Among 1441 women (mean age, 55.2±3.6 years), 202 reported preeclampsia and 112 report

SUBMITTER: Jiang X 

PROVIDER: S-EPMC11735310 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature