Incorporation of Edited MRS into Clinical Practice May Improve Care of Patients with <i>IDH</i>-Mutant Glioma.

ABSTRACT:

Background and purpose

Isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion classify adult-type diffuse gliomas into 3 tumor subtypes with distinct prognoses. We aimed to evaluate the performance of edited MR spectroscopy for glioma subtyping in a clinical setting, via the quantification of D-2-hydroxyglutarate (2HG) and cystathionine. The delay between this noninvasive classification and the integrated histomolecular analysis was also quantified.

Materials and methods

Subjects with presumed low-grade gliomas eligible for surgery (cohort 1) and subjects with IDH-mutant gliomas previously treated and with progressive disease (cohort 2) were prospectively examined with a single-voxel Mescher-Garwood point-resolved spectroscopy sequence at 3T. Spectra wer

SUBMITTER: Nichelli L 

PROVIDER: S-EPMC11735446 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature