Tests for segregation distortion in tetraploid F1 populations.

ABSTRACT:

Key message

In tetraploid F1 populations, traditional segregation distortion tests often inaccurately flag SNPs due to ignoring polyploid meiosis processes and genotype uncertainty. We develop tests that account for these factors. Genotype data from tetraploid F1 populations are often collected in breeding programs for mapping and genomic selection purposes. A common quality control procedure in these groups is to compare empirical genotype frequencies against those predicted by Mendelian segregation, where SNPs detected to have segregation distortion are discarded. However, current tests for segregation distortion are insufficient in that they do not account for double reduction and preferential pairing, two meiotic processes in polyploids that naturally change gamete frequencies,

SUBMITTER: Gerard D 

PROVIDER: S-EPMC11735573 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature