Ticam2 ablation facilitates monocyte exhaustion recovery after sepsis.

ABSTRACT: Sepsis is a leading cause of death worldwide, with most patient mortality stemming from lingering immunosuppression in sepsis survivors. This is due in part to immune dysfunction resulting from monocyte exhaustion, a phenotype of reduced antigen presentation, altered CD14/CD16 inflammatory subtypes, and disrupted cytokine production. Whereas previous research demonstrated improved sepsis survival in Ticam2^-/- mice, the contribution of TICAM2 to long-term exhaustion memory remained unknown. Using a cecal slurry injection sepsis model, we monitored the establishment and recovery of monocyte exhaustion in Ticam2^-/- mice. After one week of recovery, we profiled bone marrow and splenic reservoir monocytes in Ticam2^-/- mice and found that, in contrast to the pers

SUBMITTER: Caldwell BA 

PROVIDER: S-EPMC11735619 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature