Disparate effects of sclerostin deletion on alveolar bone and cellular cementum in mice.

ABSTRACT:

Background

Cellular cementum (CC) includes cementocytes, cells suspected to regulate CC formation or resorption as osteocytes do in bone. Sclerostin (SOST) is a secreted negative regulator of Wnt/β-catenin signaling expressed by osteocytes and cementocytes. Osteocyte SOST expression reduces bone formation. We investigated the functional importance of SOST in CC compared with alveolar bone (AB) using a Sost knockout (Sost^-/-) mouse model to better understand the role of cementocytes in CC.

Methods

Mandibles and femurs of Sost^-/- and wild-type (WT) mice were analyzed at 42 and 120 days postnatal (dpn). Maxillary first molars were bilaterally extracted at 42 dpn and both AB healing (maxillary molar sockets) and CC apposition (mandibular first molars) were

SUBMITTER: Phanrungsuwan A 

PROVIDER: S-EPMC11735692 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature